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Vitamin B12 is water soluble, meaning as long as you are taking "prescription-grade" drops, you do not have to worry that the levels are going to be diluted as they pass through your bloodstream

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However, while vitamin B12 supplements may help those with neurological function concerns or deficiencies, the evidence isnt strong enough to support its use as a standalone treatment for depression

People with digestive conditions such as Crohn's disease, celiac disease, or other inflammatory bowel conditions often have a compromised gut lining and cannot absorb oral B12 efficiently

(2021) Effects of vitamin B12 supplementation on cognitive function, depressive symptoms, and fatigue: a systematic review, meta-analysis, and meta-regression