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These two amino acids (U and Q) are not highly similar, but are both midrange in size, and polar in nature, because the selenol residue is predominantly ionized at physiological pH

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MariTide also demonstrated robust and clinically meaningful improvements in cardiometabolic parameters, including blood pressure, triglycerides and high-sensitivity C-reactive protein (hs-CRP) across doses

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Evidence of a hepatoprotective effect also exists for exenatide: this drug has been evaluated in several randomized clinical studies involving T2DM and obese patients and was shown to reduce liver enzymes, hepatic fat content, hepatic triglyceride content, and epicardial fat [78,79,80]