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doi: 10.3389/fnins.2015.00092 Received 07 February 2015 Accepted 05 March 2015 Published 20 March 2015 Volume 9 - 2015 Edited by Marc Claret, Institut d'Investigacions Biomdiques August Pi i Sunyer, Spain Reviewed by Joao Carlos Dos Reis Cardoso, University of Algarve, Portugal

The NLRP3 inflammasome is a key mediator of MSU crystalinduced inflammatory responses, and IL-1 serves as a principal downstream cytokine that amplifies inflammation

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