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People on the 2.4 mg dose lost more weight than those on other doses: Two trials (STEP 1 and STEP 3) found an average weight loss of 12% and 13% on the 2.4 mg dose in just over a year (68 weeks)

Within hours of treatment, research models begin showing increased NAD+ levels and reduced 1-MNA production, but the full spectrum of metabolic changes develops over days to weeks as downstream signaling cascades adjust to the new metabolic environment

These dosage decreases and interruption could have attenuated the growth outcomes and harms observed in the EU-IGFD Registry

Type 2 diabetes | Treatment summaries - BNF - NICE

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