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Retrieved from Hayes, M

J.MasliahE.et al

SEP-631 can block IP1 accumulation in HEK293 cells expressing MRGPRX2 in response to activation by several clinically relevant endogenous MRGPRX2 agonists (Figure 5), demonstrating that its inhibitory effect is independent of the activating agonist (i.e., the inhibitor does not show probe dependence)