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In addition to being directly activated by NAPQI, protein tyrosine phosphatase 1 B (PTP1B), 42 fibroblast growth factor 21 (FGF21), 43 and the M1 muscarinic receptor (M1R) 44 have also been found to modulate the Nrf2 signaling pathway

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doi: 10.1016/j.atherosclerosis.2013.08.033 47 SudoMLiYHiroTTakayamaTMitsumataMShiomiMet al

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This altered carnitine metabolism has been implicated in the multiple organ failure in subjects with systemic inflammatory response syndrome and toxic shock