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Consistent with this, endothelial-specific Zip14 KO mice exhibited impaired brain Mn efflux after nasal Mn supplementation and accumulated more Mn in the brain after Mn overexposure (Maiuolo et al., 2018)

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For the CAS site, there is high homology between tryptophan and tyrosine residues across the six AChEs, except for Tc AChE, which contains a phenylalanine instead of a tyrosine