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When the US Food and Drug Administration approved the first amyloid--targeting monoclonal antibody to treat Alzheimers disease in 2021, it was a big moveand a controversial one

Approval is not expected until mid-2026 or 2027 at the earliest

Rapid injection increases the likelihood of localized reactions

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doi: 10.1016/j.jep.2022.115987 19 ChoY.ShoreS

A recent study also shows that blocking IGF1R-mediated signaling reduces cell proliferation and increases cells sensitivity to the destructive effects of ionizing radiation mediated by down-regulation of BRCA2, a mediator of HR, suggesting that IGF1R is a target for enhancing tumor sensitivity to radiotherapy (Venkatachalam et al., 2017)