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High concentrations for IV use should be diluted in normal saline or another compatible IV fluid before administration

Genetic factors affecting receptor expression or downstream signaling may limit effectiveness

Post-Surgical Recovery After orthopedic surgery -- ACL reconstruction, rotator cuff repair, hip arthroscopy -- PRP can be injected directly at the surgical site

These drawbacks are common to all injections, however, not just vitamin B12

The very same pathways that make it a regenerative jack-of-all-trades could also pose dangers especially regarding cancer and unregulated cell growth