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12-month neurological and psychiatric outcomes of semaglutide use for type 2 diabetes: a propensity-score matched cohort study
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GLP1/E therapy also elicited specific changes in the hypothalamic proteomic profile in PNA mice, upregulating proteins involved in the metabolism of non-coding RNA, signaling of nuclear receptor and estrogen-dependent gene expression and downregulating pathways involved in apoptosis, signaling by insulin receptor and cellular responses to starvation
J Biol Chem (2010) 285(51):4018091
Individuals who rapidly lose a large amount of weight commonly regain most of the weight in the subsequent 5 years
However, results may vary from person to person
