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A recent phase III trial testing exendin-4 did not show an improvement, which may be linked to the lack of insulin desensitization in the study participants

S-A-GSH is well-suited for oral ingestion because this acetyl group protects glutathione from breaking down in the gastrointestinal tract

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Babazadeh D, Wyatt S, Steinberg FM

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Loboda A, Damulewicz M, Pyza E, Jozkowicz A, Dulak J (2016) Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism