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1 Introduction Incidence rates of type 2 diabetes (T2D) have reached pandemic proportions, affecting more than 422 million individuals worldwide ( Figure 1 )

Concurrently, Y205 2.75b shifts inward to approach ECL2, making a hydrogen bond with R299 ECL2 and establishing a polar network involving Q221 ECL1 and E21 P to stabilize binding

No GLP-1 drug is approved for cognitive indications

Dallman et al., 2005

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