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Photoprotective and Antioxidant Signaling Consistent with MC1R engagement, MT-2 has been shown in in-vitro models to reduce UV-induced cyclobutane pyrimidine dimer (CPD) formation and attenuate reactive oxygen species (ROS) accumulation in melanocytes, paralleling the photoprotective signaling profile documented for MT-1 (Abdel-Malek et al., Cancer Research, 2005)

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doi: 10.1080/15376516.2018.1491663 88 BoucherJGGagnRRowan-CarrollABoudreauAYaukCLAtlasE

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