This research led to the development of liraglutide , known as Saxenda , the first GLP-1-based drug approved for obesity treatment
Even with coverage, some face $150 copayments for refills
Not Drinking Enough Water GLP-1 medications can reduce your thirst as well as your appetite, making dehydration easier than you might expect
The injection should be placed in the upper part of the outer half of each buttock, at least four finger widths away from the gluteal cleft
However, because large amounts of fat can worsen nausea or acid reflux in some people taking GLP-1 medications, many people find it more comfortable to include smaller portions throughout the day, such as a drizzle of olive oil on vegetables, a tablespoon of almond butter in a smoothie, a quarter of an avocado with lunch, rather than eating one high-fat meal
"This has been shown in studies, often [with] fewer side effects." More oral GLP-1s may be coming in 2026, according to Decotiis, including an Orforglipron application by Lilly and a new combination Novo Nordisk drug, which is pending approval later next year
