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Louis and a leading figure in NAD biology, and Leonard Guarente, Ph.D., an American biologist and Novartis Professor of Biology at MIT, published a landmark finding showing that the longevity-related protein Sir2 functions as an NAD-dependent enzyme, linking cellular energy metabolism to gene regulation pathways involved in aging

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Molecular mechanisms of aging underlying the incidence and progression of CVD have not been sufficiently explored as a potential treatment target