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The iAUC INR was reduced by 28% with SNAC alone plus warfarin, and a similar reduction was observed when patients who mistakenly received the lower dose of warfarin were excluded
But cheaper does not automatically mean equivalent
More recently, the SELECT trial has provided evidence for cardiovascular outcome benefits in people with established cardiovascular disease
doi: 10.1016/j.tibtech.2019.04.001, 265
Providers should assess patient tolerance and discontinue use if adverse reactions occur
In the comprehensive preclinical studies, MDR-001 has demonstrated excellent functional potency and selectivity, with favorable ADME properties and oral bioavailability, as well as desirable pharmacokinetics and tolerability
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