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BMSCs promote the differentiation of NSCs into oligodendrocytes via mediating Id2 and Olig expression through BMP/Smad signaling pathway
During this phase, injection frequency is higher to build systemic levels of the peptide and begin the actin regulation and angiogenesis responses
High doses of vitamin C or iron can exacerbate oxidative stress [15]
In addition, pro-inflammatory cytokines can act to steal tryptophan away from serotonin and melatonin pathways (via up-regulation of the enzymes IDO and TDO), increasing the activity of the NMDA agonist quinolinic acid, and further antagonising stimulation of NMDA pathways, which subsequently exacerbates mood and sleep issues