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The theory holds that high lactic acid buildup makes IGF-1 receptors more receptive, so injecting into muscles about to be trained maximizes local effects

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[DOI] [PMC free article] [PubMed] [Google Scholar] 36.Bilski R., Kupczyk D., Woniak A

IGF-1 LR3 IGF-1 LR3 is a modified recombinant insulin-like growth factor 1 analogue of 83 amino acids synthesised with an N-terminal extension and Arg3 substitution, studied in anabolic signalling research for its role in increasing the free fraction of circulating IGF-1 (~3 vs native)

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