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Animal studies further confirm these anti-inflammatory effects, with high-fat-fed rats exhibiting reduced macrophage infiltration, lower circulating pro-inflammatory cytokines, and improved lipid metabolism due to the inhibition of lipogenesis and enhancement of fatty acid oxidation (Limbad et al., 2024

Additionally, we found PPARA to be significantly positively enriched in both BWS lines, and it was the highest positively-enriched gene of this process in BWS 1

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Nicolson R, Rapoport JL (1999)

( Mutation detection and gene fusion analysis were performed using the customized panels QIASeq targeted DNA Panel for Solid Tumors (Qiagen) and QIAseq targeted RNAscan Panel (Qiagen)