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TUNEL-positive cells and 4-HNE accumulation were observed within TLS in both sulfasalazine-treated and vehicle-treated mice, while cleaved caspase-3, an apoptosis marker, was not evident in either group (Figure 5C)

We were able to detect transcription factor binding to the region immediately surrounding rs2880961, but we did not observe striking differences in binding to WT and variant SNP sequences based on ChIP assays performed with three transcription factors (Fig