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Recently, the STEP-HFpEF trial enrolled 529 non-diabetic patients with HFpEF and obesity, who were randomly assigned to receive either once-weekly semaglutide (2.4 mg) or placebo for 52 weeks

Increased Inflammation Estrogen exhibits anti-inflammatory effects by modulating the immune response and reducing the production of pro-inflammatory cytokines, which are signaling proteins that can exacerbate inflammation

Results begin subjectively (sleep, energy, recovery) at 2-3 weeks and become visibly dramatic by 3-6 months

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