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In clinical studies, some people who used tirzepatide for weight loss lost between 15%-21% of their body weight

However, chronic excessive cortisol secretion due to HPA axis hyperactivity promotes inflammation by downregulating glucocorticoid receptors, which are typically involved in anti-inflammatory responses

Results in the study demonstrate that IGF-1 induces the opposite effects since the IGF-1 deficit reduces the expression of glucose-6-phosphatase and phosphoenolpyruvate carboxylase-1

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If you're looking to improve your skin tone, detox your body, or slow aging and have no medical contraindications glutathione tablets may be a helpful addition

It reduces appetite by acting on hunger centres in the brain, slows stomach emptying so you feel full longer, improves insulin secretion, reduces glucagon production, and helps target visceral (belly) fat