An earlier 12-week trial in 300 obese adults produced a genuine positive signal the 1 mg daily dosing arm showed a statistically significant 2.8 kg mean weight loss versus 0.8 kg in the placebo group and that result is what justified moving into the larger Phase IIb trial
If you need to recover quickly from an illness that depleted your B12 reserves or have recently discovered you have a B12 deficiency that is impacting your quality of life, one solution is to give your body a larger dose of B12 all at once
Ong C, Lim J, Ng C, et al
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