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The ESSENCE trial showed that 62.9% of participants taking Wegovy achieved resolution of MASH after 72 weeks, with over a third showing improvement in liver scarring

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This balance between efficacy and safety is central to interpreting the data and will likely shape how future studies prioritise one endpoint over the other

Although not a significant function of the PPP, it can operate to metabolize dietary pentose sugars derived from the digestion of nucleic acids as well as to rearrange the carbon skeletons of dietary carbohydrates into glycolytic and /or gluconeogenic intermediates