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16a-c,h), at which 354 was still present in the medium as shown by LC/MS analyses (Supplementary Fig

Finally, NAC supports the Nrf2-dependent transcription pathway, a genetic cellular defense mechanism that upregulates the production of endogenous antioxidant enzymes, providing a robust buffer against the oxidative damage to DNA, proteins, and lipids that naturally occurs with aging and chronic illness

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Based on the high abundance of TLR4 in microglia, we hypothesize that BDNF inhibits neuroinflammation by targeting TLR4