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Hemolytic anemia is the main pathological manifestation of -thal, and hemolysis occurs for two reasons: premature destruction of erythroid precursor cells, and shortening of the lifespan of mature erythrocytes in the circulation ( Anemia in individuals who have -thal is primarily triggered by ineffective erythropoiesis (IE)

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For example, the redox activitiy of p66Shc within mitochondria has been shown to generate H 2 O 2 in the absence of superoxide through oxidation of cytochrome c ( 2 O 2