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Defects in the BCAA metabolism-related gene, protein phosphatase Mg 2+ /Mn 2+ -dependent 1 K (PPM1K), can disrupt energy metabolism homeostasis within the follicular microenvironment, potentially leading to PCOS-like phenotypes 15

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Weight loss typically follows a pattern: a modest initial drop (often partially water weight), followed by steady fat loss of 1 to 2 pounds per week at therapeutic doses

Other evidence has shown that omega-3 fatty acids could reduce proteinuria in patients with CKD, and reduce inflammation and triglycerides in dialysis patients