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Most gastrointestinal side effects resolve by week 12, leaving minimal symptoms during months 4-11

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This framework also explains something clinicians have observed but struggled to articulate: why GLP-1 medications seem to help patients with conditions that have no obvious connection to obesity

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Clinical translation has been highly successful, with Phase 2 obesity studies demonstrating dose-dependent mean body weight reductions of up to 24.2% after 48 weeks of once-weekly treatment, accompanied by substantial improvements in glycemic control and cardiometabolic biomarkers

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Activation of GIP receptors may further support fat metabolism and insulin sensitivity, whilst glucagon receptor agonism is believed to increase energy expenditure and promote the breakdown of stored fat (lipolysis)

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Overweight and obesity management (NG246) full guideline PDF NICE

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