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PMID: 50 HoylerTKloseCSSouabniATurqueti-NevesAPfeiferDRawlinsELet al

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Statistical analysis Using data generated from a pilot study and G*Power 3.1 software (Dsseldorf, Germany), it was determined that a sample size of 15 would provide 80% power to detect an increase in CNS GSH concentrations between pre- and post-administration values, with an accepted alpha value of 0.2

Jagust P, Alcal S, Sainz Jr B, Heeschen C, Sancho P

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Additionally, it is important to note that NR readily degrades in human and rodent plasma, and NMN degrades in human plasma, suggesting low systemic stability of the molecules when administered orally 68,124,125