The skyrocketing demand for GLP-1 weight-loss medications has led to a surge in compounding pharmacies producing similar products at lower prices, but researchers warn that these medications are not always as safe as they claim
10.1056/NEJMoa2028395 58 PanQ.LinS.LiY.LiuL.LiX.GaoX.et al (2021)
Many people microdosing GLP-1 medications are taking a compounded GLP-1, which means the drug was made in a compounded pharmacy and not approved by the FDA for safety, quality or efficiency
In a separate trial involving patients with type 2 diabetes, Retatrutide reduced A1C levels, which measure blood sugar, by up to 2 percentage points and produced an average weight loss of 16.8% after 40 weeks
Vascular located monocytes/macrophages engulf oxidized-LDL (ox-LDL), generating foam cells which release a plethora of pro-inflammatory mediators
ClinicalTrials.gov (2017)