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A meta-analysis ( n = 19 studies) of Vit-E supplementation (mean dosage: 384 mg/d) has shown to reduce OxS in hemodialysis patients 504

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In addition, IRE1 kinase can up-regulated the expression of apoptosis signal regulated kinase 1(ASK1) and then activate c-Jun N-terminal kinase (JNK) to promote apoptosis through the inhibition of BCL-2 protein family (64, 65)