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The comparison between injectable and oral peptides provides broader context on these delivery methods

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Although no significant change was observed in the bone formation marker P1NP, the semaglutide group showed a significant increase in the bone resorption marker CTX and a reduction in areal BMD at both the lumbar spine and total hip

The next-generation of transformative peptide therapeutics is therefore likely to emerge not from novel hormone discovery, but from the systematic rediscovery and reengineering of endogenous peptidereceptor systems long considered too complex to pursue

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It is important to note that all dosing regimens described here are investigational