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At a dose of 100 g/ml, the extract displayed inhibition on the PGE2, NO, IL-6, TNF-, and IL-1 expression and the activation of p38 MAPK, extracellular signal-regulated kinase (ERK), and JNK in LPS-activated RAW 264.7 cells

Transcobalamin (TC) (he active form of B 12 )

10.1038/s42255-024-01041-8 132 YustaB.BaggioL

Freezing causes water in the solution to form ice crystals, and those crystals physically tear apart peptide molecules