This effect was abrogated by inhibiting NOSs or guanylate cyclase, implicating NO/cGMP signaling pathway in this process (Aquilano et al., 2013)
Three engineered strains W303-1b/G, W303-1b/F and W303-1b/P displayed higher activities for synthesizing GSH than the parental strain
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This condition can contribute to various diseases, including cardiovascular diseases, neurodegenerative disorders, and cancer
Additionally, by lowering the amount of redox-active iron available, several mitochondrial proteins, such as NFS1-ISCU26, CISD1, and CISD2, can negatively control ferroptosis (Zhang et al., 2021)