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Further investigation into the role of cellular pyroptosis in regulating follicular atresia may reveal promising therapeutic targets for delaying the onset of DOR

It should be noted that GIPR antagonism paradoxically produces additive weight loss when paired to GLP-1R agonism in preclinical studies (5860) and that this mechanism appears relevant in patients with obesity (61)

However, in case of persistent and/or larger ER stress prevailing over the cellular defensive mechanisms, cell injury and activation of various pro-apoptotic signaling pathways take place (Oyadomari and Mori, 2004

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Ocular neovascularization