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Finally, as detailed clinical indications were not consistently available in the national administrative dataset, future research should employ a nested casecontrol design to enable more precise characterization of these variables

Expression of melanocyte specific markers in greying human hair follicles The correlation between the pigmentation status and the melanocyte-specific markers (GP100, Tyrosinase related protein-1 (TRP-1) and Tyrosinase (TYR) was evaluated in human scalp hair bulbs

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What it does is curb excess melanin production and when melanin goes unchecked, that's usually when dark spots and patchy tone start showing up