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The failure of aerosolized superoxide dismutase to modify pulmonary oxygen toxicity

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Patients with pernicious anaemia, malabsorption disorders (such as Crohn's disease or coeliac disease), or following gastric surgery require regular B12 supplementation to prevent serious complications including megaloblastic anaemia and neurological damage

Additionally, antioxidants target huge amounts of reactive oxygen intermediates and are unable to modulate specific intermediate in the oxidative reaction, and subsequently leading several therapeutic strategies are unfocused