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Inhibition of Gln utilization with DON and its prodrugs JHU083 and DRP-104 boost the anti-tumor immune response [92,93,94], suggesting the rationale of their combination with immune checkpoint inhibitors

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The peptide sequence, alanine-histidine-lysine bound to copper, was chosen because of how it interacts with growth factor receptors and anti-apoptotic pathways

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