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In the Phase 2 trial, participants on the 12 mg dose were still on a steep weight loss trajectory at 48 weeks, losing roughly 5-6 pounds per month even late in the treatment period

Retatrutide Clinical Studies Registry

They may try to increase the likelihood of approval on the second try by including additional documentation or further evidence of medical necessity

Nature 535 , 182186 (2016)

Adapting this for semaglutide delivery could mean paying implementers when agreed public health outcomes are metsomething that could incentivise innovation in delivery

This calibrated potency pattern differentiates retatrutide from GLP-1 monotherapies and GLP-1/GIP dual agonists, contributing to its broad metabolic effects