Targeting ULK1 decreases IFN-mediated resistance to immune checkpoint inhibitors
In acid sphingomyelinase knock-out mice, which mimic a neurovisceral acid sphingomyelinase deficiency (ASMD) characterized by cellular accumulation of sphingomyelin, the effects of a choline-free diet decreased the activation of liver macrophages and microglia, but it did not significantly alter sphingomyelin levels due to compensatory mechanisms involving methionine metabolism (101)
Serious side effects and warnings Victoza carries a Boxed Warning for thyroid C-cell tumors in rats and mice, but it is unknown whether Victoza would cause this type of cancer in humans
A quick note on the idea of injecting near a site of interest : some recovery-oriented research practice describes placing a compound like BPC-157 subcutaneously close to the area being studied (for example, near a specific joint or soft-tissue region), on the theory of a more local effect, versus a general systemic SubQ site like the abdomen
Subsequent reviews have reinforced this finding, suggesting GLP-1s may dampen reward signaling in the brains dopamine pathways, which are involved in addiction and compulsive behaviors (Kalra et al., 2024
Nervous system health
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