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We do not have dose-response data to say whether sub-maximal doses of GLP-1 RAs (for example, in patients who do not want or cannot tolerate the full dose) are effective

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Mechanistic studies have established that Dihexas procognitive and synaptogenic effects are mediated by the hepatocyte growth factor (HGF) / c-Met receptor system rather than by the classical AT 4 receptor, despite Dihexas structural origin as an angiotensin IV derivative