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Importantly, these improvements persisted even when researchers controlled for weight loss, proving that GLP-1 activation has direct cardiovascular benefits beyond obesity treatment

Months 2-3 usually show accelerated weight loss as the body adjusts to lower calorie intake and the medication reaches steady-state levels in your bloodstream

Hoffmann et al., 2026

2) What is the main difference between tirzepatide and semaglutide

It takes weeks or months of consistently lower, less varied intake before your levels actually drop