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The TM-score is a number between 0 and 1, with a value greater than 0.5, indicating that the models topology was predicted correctly

however, the underlying mechanisms are uncertain, due to the fact that some TH actions on glucose tolerance and insulin sensitivity in different tissues may have divergent influences on blood glucose levels 35

Nov 11 2021;9(11)doi:10.3390/toxics9110299

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Association of organic cation transporter 1 with intolerance to metformin in type 2 diabetes: a GoDARTS study