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Future research should consider composite strategies, such as microbiota-responsive or time-dependent coatings, to further refine pH-dependent release control and thereby improve formulation stability and strengthen the translational potential of this platform

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Avoid repeated freeze-thaw cycles unless freezing in single-use aliquots

Since some of the pleiotropic actions of metformin are associated with AMPK activation 15 , we examined if metformin treatment affects beta cell survival

However, even in these patients, ALC failed to improve the glycemic profile

Some side effects are known and documented