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Frequencies and patterns of co-occurrence (Extended Data Fig

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2008;43(6):E259

204 Similarly, administration of the PRMT5 inhibitor PJ-68 in a CML mouse model with high expression of PRMT5 LSCs could deplete DVL3, thereby inhibiting Wnt/-catenin signaling and significantly prolonging the survival time of a retroviral BCR-ABL-driven CML mouse model

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Discussion The present study used the findings of the SUSTAIN 7 RCT of 1201 patients with T2D to compare the cost of bringing a patient to each of five defined clinical targets in the trial with injectable once-weekly semaglutide 0.5 mg relative to once-weekly dulaglutide 0.75 mg