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Basic experimentation in early human development is hampered by the paucity of fetal material available to study typical developmental trajectories, by ethical issues associated with using human fetal tissues, and by a dearth of knowledge of the genetic and molecular programs that direct human embryogenesis and gametogenesis

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Understanding these interactions helps avoid serious complications like adrenal suppression or increased infection risk

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Thats the pathway that tells endothelial cells to produce nitric oxide, which is the signal for vasodilation, angiogenesis, and blood flow recovery