One major study found an average weight loss of nearly 21% with tirzepatide versus about 13% with semaglutide over 72 weeks in adults with obesity but not diabetes
[14] [15] Importantly, the FDA label for Zepbound includes specific guidance regarding pregnancy
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At 5 mg, participants lost an average of approximately 15% of body weight over 72 weeks
So far, the study results have shown a pharmacokinetic profile that supports once-daily dosing, a safety profile consistent with previous Danuglipron studies, including no observed increase in liver enzymes among over 1400 study participants