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This could potentially help these patients maintain or even increase their weight loss. Previous research on weight regain after GLP-1 receptor agonist discontinuation is mixed

One study found that over 90% of GLP1 users failed to meet requirements for Vitamin D, potassium and choline (Spreckley 2026)

But our craving for sweetness in scent isnt new

The observations in SUSTAIN-6 are predictable, given that intensified versus conventional insulin therapy is well known to have the capacity to precipitate initial worsening of retinopathy in patients with T2D with advanced preexisting retinopathy, as shown in the Diabetes Control and Complications Trial (82)

At 4mg, the phase 2 trial showed 17.1% average weight loss at 48 weeks, which exceeds the maximum dose of semaglutide (14.9%) in its own trial