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In these settings, glucose dysregulation, visceral adiposity, fatty liver, vascular inflammation, and chronic low-grade inflammation often reinforce one another, creating a cascade of metabolic stress that accelerates functional decline

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In experimental models with hepatic steatosis induced by a fat-rich diet, a diminution was found of transcription due to the diminished levels of mRNA of the components AMPK-PGC-1, NRF-2, and -ATP synthase [52]

Duke Sanford School of Public Policy faculty member Jonathan Zhang is an economist who works on health policy, health economics and public finance

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Two 2025 reviews, Paschou IA et al