Preclinical data available so far have highlighted metabolic efficacy and its superior performance to dual agonists in reducing cardiovascular risk factors, such as plasma glucose levels, and body weight (Finan et al., 2015
and Kvist, A-P
While many coronaviruses utilize peptidases, such as ACE2, dipeptidyl peptidase 4, aminopeptidase N, as their cellular receptors, SARS-CoV, SARS-CoV-2 and HCoV-NL63 utilize ACE2 as their receptors thus disrupting the renin-angiotensin system (Verdecchia et al., 2020)
Compounded semaglutide is dramatically cheaper than brand-name Ozempic because it avoids patent premiums (no monopoly pricing during patent protection), eliminates brand-name marketing expenses (billions spent on advertising and sales), uses direct-to-consumer distribution (cutting out multiple middlemen and markups), employs simpler packaging (standard vials versus sophisticated pen devices), operates with lower overhead (efficient telehealth models versus traditional pharmaceutical infrastructure), and doesnt need to recover research and development costs (using already-developed pharmaceutical ingredients)
References 1 New England Journal of Medicine (2023)Once-Weekly Semaglutide for Weight Management (STEP program
